Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D*
Identifieur interne : 001184 ( Main/Exploration ); précédent : 001183; suivant : 001185Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D*
Auteurs : Natalia Davydova ; Nicole C. Harris ; Sally Roufail ; Sophie Paquet-Fifield ; Musarat Ishaq ; Victor A. Streltsov ; Steven P. Williams ; Tara Karnezis ; Steven A. Stacker ; Marc G. AchenSource :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Anticorps neutralisants, Cellules cultivées, Derme (anatomopathologie), Derme (métabolisme), Endothélium vasculaire (anatomopathologie), Endothélium vasculaire (métabolisme), Facteur de croissance endothéliale vasculaire de type C (), Facteur de croissance endothéliale vasculaire de type C (génétique), Facteur de croissance endothéliale vasculaire de type C (métabolisme), Facteur de croissance endothéliale vasculaire de type D (), Facteur de croissance endothéliale vasculaire de type D (génétique), Facteur de croissance endothéliale vasculaire de type D (métabolisme), Femelle, Humains, Lymphangiogenèse, Mutagenèse dirigée, Mutation (génétique), Néovascularisation pathologique (anatomopathologie), Néovascularisation pathologique (métabolisme), Récepteur-2 au facteur croissance endothéliale vasculaire (génétique), Récepteur-2 au facteur croissance endothéliale vasculaire (métabolisme), Récepteur-3 au facteur croissance endothéliale vasculaire (génétique), Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme), Souris SCID, Souris de lignée NOD, Transduction du signal, Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (métabolisme).
- MESH :
- anatomopathologie : Derme, Endothélium vasculaire, Néovascularisation pathologique, Vaisseaux lymphatiques.
- génétique : Facteur de croissance endothéliale vasculaire de type C, Facteur de croissance endothéliale vasculaire de type D, Mutation, Récepteur-2 au facteur croissance endothéliale vasculaire, Récepteur-3 au facteur croissance endothéliale vasculaire.
- métabolisme : Derme, Endothélium vasculaire, Facteur de croissance endothéliale vasculaire de type C, Facteur de croissance endothéliale vasculaire de type D, Néovascularisation pathologique, Récepteur-2 au facteur croissance endothéliale vasculaire, Récepteur-3 au facteur croissance endothéliale vasculaire, Vaisseaux lymphatiques.
- Animaux, Anticorps neutralisants, Cellules cultivées, Facteur de croissance endothéliale vasculaire de type C, Facteur de croissance endothéliale vasculaire de type D, Femelle, Humains, Lymphangiogenèse, Mutagenèse dirigée, Souris SCID, Souris de lignée NOD, Transduction du signal.
English descriptors
- KwdEn :
- Animals, Antibodies, Neutralizing, Cells, Cultured, Dermis (metabolism), Dermis (pathology), Endothelium, Vascular (metabolism), Endothelium, Vascular (pathology), Female, Humans, Lymphangiogenesis, Lymphatic Vessels (metabolism), Lymphatic Vessels (pathology), Mice, Inbred NOD, Mice, SCID, Mutagenesis, Site-Directed, Mutation (genetics), Neovascularization, Pathologic (metabolism), Neovascularization, Pathologic (pathology), Signal Transduction, Vascular Endothelial Growth Factor C (chemistry), Vascular Endothelial Growth Factor C (genetics), Vascular Endothelial Growth Factor C (metabolism), Vascular Endothelial Growth Factor D (chemistry), Vascular Endothelial Growth Factor D (genetics), Vascular Endothelial Growth Factor D (metabolism), Vascular Endothelial Growth Factor Receptor-2 (genetics), Vascular Endothelial Growth Factor Receptor-2 (metabolism), Vascular Endothelial Growth Factor Receptor-3 (genetics), Vascular Endothelial Growth Factor Receptor-3 (metabolism).
- MESH :
- chemical , chemistry : Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D.
- chemical , genetics : Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D, Vascular Endothelial Growth Factor Receptor-2, Vascular Endothelial Growth Factor Receptor-3.
- chemical , metabolism : Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D, Vascular Endothelial Growth Factor Receptor-2, Vascular Endothelial Growth Factor Receptor-3.
- chemical : Antibodies, Neutralizing.
- genetics : Mutation.
- metabolism : Dermis, Endothelium, Vascular, Lymphatic Vessels, Neovascularization, Pathologic.
- pathology : Dermis, Endothelium, Vascular, Lymphatic Vessels, Neovascularization, Pathologic.
- Animals, Cells, Cultured, Female, Humans, Lymphangiogenesis, Mice, Inbred NOD, Mice, SCID, Mutagenesis, Site-Directed, Signal Transduction.
Abstract
VEGF-C and VEGF-D are secreted glycoproteins that induce angiogenesis and lymphangiogenesis in cancer, thereby promoting tumor growth and spread. They exhibit structural homology and activate VEGFR-2 and VEGFR-3, receptors on endothelial cells that signal for growth of blood vessels and lymphatics. VEGF-C and VEGF-D were thought to exhibit similar bioactivities, yet recent studies indicated distinct signaling mechanisms (
Url:
DOI: 10.1074/jbc.M116.736801
PubMed: 27852824
PubMed Central: 5207153
Affiliations:
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Harris</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Roufail, Sally" sort="Roufail, Sally" uniqKey="Roufail S" first="Sally" last="Roufail">Sally Roufail</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Paquet Fifield, Sophie" sort="Paquet Fifield, Sophie" uniqKey="Paquet Fifield S" first="Sophie" last="Paquet-Fifield">Sophie Paquet-Fifield</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ishaq, Musarat" sort="Ishaq, Musarat" uniqKey="Ishaq M" first="Musarat" last="Ishaq">Musarat Ishaq</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Streltsov, Victor A" sort="Streltsov, Victor A" uniqKey="Streltsov V" first="Victor A." last="Streltsov">Victor A. Streltsov</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Williams, Steven P" sort="Williams, Steven P" uniqKey="Williams S" first="Steven P." last="Williams">Steven P. Williams</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Karnezis, Tara" sort="Karnezis, Tara" uniqKey="Karnezis T" first="Tara" last="Karnezis">Tara Karnezis</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Stacker, Steven A" sort="Stacker, Steven A" uniqKey="Stacker S" first="Steven A." last="Stacker">Steven A. Stacker</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Achen, Marc G" sort="Achen, Marc G" uniqKey="Achen M" first="Marc G." last="Achen">Marc G. Achen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Biological Chemistry</title><idno type="ISSN">0021-9258</idno><idno type="eISSN">1083-351X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Neutralizing</term><term>Cells, Cultured</term><term>Dermis (metabolism)</term><term>Dermis (pathology)</term><term>Endothelium, Vascular (metabolism)</term><term>Endothelium, Vascular (pathology)</term><term>Female</term><term>Humans</term><term>Lymphangiogenesis</term><term>Lymphatic Vessels (metabolism)</term><term>Lymphatic Vessels (pathology)</term><term>Mice, Inbred NOD</term><term>Mice, SCID</term><term>Mutagenesis, Site-Directed</term><term>Mutation (genetics)</term><term>Neovascularization, Pathologic (metabolism)</term><term>Neovascularization, Pathologic (pathology)</term><term>Signal Transduction</term><term>Vascular Endothelial Growth Factor C (chemistry)</term><term>Vascular Endothelial Growth Factor C (genetics)</term><term>Vascular Endothelial Growth Factor C (metabolism)</term><term>Vascular Endothelial Growth Factor D (chemistry)</term><term>Vascular Endothelial Growth Factor D (genetics)</term><term>Vascular Endothelial Growth Factor D (metabolism)</term><term>Vascular Endothelial Growth Factor Receptor-2 (genetics)</term><term>Vascular Endothelial Growth Factor Receptor-2 (metabolism)</term><term>Vascular Endothelial Growth Factor Receptor-3 (genetics)</term><term>Vascular Endothelial Growth Factor Receptor-3 (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps neutralisants</term><term>Cellules cultivées</term><term>Derme (anatomopathologie)</term><term>Derme (métabolisme)</term><term>Endothélium vasculaire (anatomopathologie)</term><term>Endothélium vasculaire (métabolisme)</term><term>Facteur de croissance endothéliale vasculaire de type C ()</term><term>Facteur de croissance endothéliale vasculaire de type C (génétique)</term><term>Facteur de croissance endothéliale vasculaire de type C (métabolisme)</term><term>Facteur de croissance endothéliale vasculaire de type D ()</term><term>Facteur de croissance endothéliale vasculaire de type D (génétique)</term><term>Facteur de croissance endothéliale vasculaire de type D (métabolisme)</term><term>Femelle</term><term>Humains</term><term>Lymphangiogenèse</term><term>Mutagenèse dirigée</term><term>Mutation (génétique)</term><term>Néovascularisation pathologique (anatomopathologie)</term><term>Néovascularisation pathologique (métabolisme)</term><term>Récepteur-2 au facteur croissance endothéliale vasculaire (génétique)</term><term>Récepteur-2 au facteur croissance endothéliale vasculaire (métabolisme)</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire (génétique)</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme)</term><term>Souris SCID</term><term>Souris de lignée NOD</term><term>Transduction du signal</term><term>Vaisseaux lymphatiques (anatomopathologie)</term><term>Vaisseaux lymphatiques (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term><term>Vascular Endothelial Growth Factor D</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term><term>Vascular Endothelial Growth Factor D</term><term>Vascular Endothelial Growth Factor Receptor-2</term><term>Vascular Endothelial Growth Factor Receptor-3</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term><term>Vascular Endothelial Growth Factor D</term><term>Vascular Endothelial Growth Factor Receptor-2</term><term>Vascular Endothelial Growth Factor Receptor-3</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Neutralizing</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Derme</term><term>Endothélium vasculaire</term><term>Néovascularisation pathologique</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mutation</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type C</term><term>Facteur de croissance endothéliale vasculaire de type D</term><term>Mutation</term><term>Récepteur-2 au facteur croissance endothéliale vasculaire</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dermis</term><term>Endothelium, Vascular</term><term>Lymphatic Vessels</term><term>Neovascularization, Pathologic</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Derme</term><term>Endothélium vasculaire</term><term>Facteur de croissance endothéliale vasculaire de type C</term><term>Facteur de croissance endothéliale vasculaire de type D</term><term>Néovascularisation pathologique</term><term>Récepteur-2 au facteur croissance endothéliale vasculaire</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dermis</term><term>Endothelium, Vascular</term><term>Lymphatic Vessels</term><term>Neovascularization, Pathologic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Female</term><term>Humans</term><term>Lymphangiogenesis</term><term>Mice, Inbred NOD</term><term>Mice, SCID</term><term>Mutagenesis, Site-Directed</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Anticorps neutralisants</term><term>Cellules cultivées</term><term>Facteur de croissance endothéliale vasculaire de type C</term><term>Facteur de croissance endothéliale vasculaire de type D</term><term>Femelle</term><term>Humains</term><term>Lymphangiogenèse</term><term>Mutagenèse dirigée</term><term>Souris SCID</term><term>Souris de lignée NOD</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>VEGF-C and VEGF-D are secreted glycoproteins that induce angiogenesis and lymphangiogenesis in cancer, thereby promoting tumor growth and spread. They exhibit structural homology and activate VEGFR-2 and VEGFR-3, receptors on endothelial cells that signal for growth of blood vessels and lymphatics. VEGF-C and VEGF-D were thought to exhibit similar bioactivities, yet recent studies indicated distinct signaling mechanisms (<italic>e.g.</italic> tumor-derived VEGF-C promoted expression of the prostaglandin biosynthetic enzyme COX-2 in lymphatics, a response thought to facilitate metastasis via the lymphatic vasculature, whereas VEGF-D did not). Here we explore the basis of the distinct bioactivities of VEGF-D using a neutralizing antibody, peptide mapping, and mutagenesis to demonstrate that the N-terminal α-helix of mature VEGF-D (Phe<sup>93</sup>–Arg<sup>108</sup>) is critical for binding VEGFR-2 and VEGFR-3. Importantly, the N-terminal part of this α-helix, from Phe<sup>93</sup> to Thr<sup>98</sup>, is required for binding VEGFR-3 but not VEGFR-2. Surprisingly, the corresponding part of the α-helix in mature VEGF-C did not influence binding to either VEGFR-2 or VEGFR-3, indicating distinct determinants of receptor binding by these growth factors. A variant of mature VEGF-D harboring a mutation in the N-terminal α-helix, D103A, exhibited enhanced potency for activating VEGFR-3, was able to promote increased COX-2 mRNA levels in lymphatic endothelial cells, and had enhanced capacity to induce lymphatic sprouting <italic>in vivo</italic>. This mutant may be useful for developing protein-based therapeutics to drive lymphangiogenesis in clinical settings, such as lymphedema. Our studies shed light on the VEGF-D structure/function relationship and provide a basis for understanding functional differences compared with VEGF-C.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Stacker, S A" uniqKey="Stacker S">S. A. Stacker</name></author><author><name sortKey="Williams, S P" uniqKey="Williams S">S. P. Williams</name></author><author><name sortKey="Karnezis, T" uniqKey="Karnezis T">T. Karnezis</name></author><author><name sortKey="Shayan, R" uniqKey="Shayan R">R. Shayan</name></author><author><name sortKey="Fox, S B" uniqKey="Fox S">S. B. Fox</name></author><author><name sortKey="Achen, M G" uniqKey="Achen M">M. G. Achen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, W" uniqKey="Zheng W">W. Zheng</name></author><author><name sortKey="Aspelund, A" uniqKey="Aspelund A">A. Aspelund</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K. Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duong, T" uniqKey="Duong T">T. Duong</name></author><author><name sortKey="Koltowska, K" uniqKey="Koltowska K">K. Koltowska</name></author><author><name sortKey="Pichol Thievend, C" uniqKey="Pichol Thievend C">C. Pichol-Thievend</name></author><author><name sortKey="Le Guen, L" uniqKey="Le Guen L">L. Le Guen</name></author><author><name sortKey="Fontaine, F" uniqKey="Fontaine F">F. Fontaine</name></author><author><name sortKey="Smith, K A" uniqKey="Smith K">K. A. Smith</name></author><author><name sortKey="Truong, V" uniqKey="Truong V">V. Truong</name></author><author><name sortKey="Skoczylas, R" uniqKey="Skoczylas R">R. Skoczylas</name></author><author><name sortKey="Stacker, S A" uniqKey="Stacker S">S. A. Stacker</name></author><author><name sortKey="Achen, M G" uniqKey="Achen M">M. G. Achen</name></author><author><name sortKey="Koopman, P" uniqKey="Koopman P">P. Koopman</name></author><author><name sortKey="Hogan, B M" uniqKey="Hogan B">B. M. Hogan</name></author><author><name sortKey="Francois, M" uniqKey="Francois M">M. Francois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ober, E A" uniqKey="Ober E">E. A. 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Harris</name><name sortKey="Ishaq, Musarat" sort="Ishaq, Musarat" uniqKey="Ishaq M" first="Musarat" last="Ishaq">Musarat Ishaq</name><name sortKey="Karnezis, Tara" sort="Karnezis, Tara" uniqKey="Karnezis T" first="Tara" last="Karnezis">Tara Karnezis</name><name sortKey="Paquet Fifield, Sophie" sort="Paquet Fifield, Sophie" uniqKey="Paquet Fifield S" first="Sophie" last="Paquet-Fifield">Sophie Paquet-Fifield</name><name sortKey="Roufail, Sally" sort="Roufail, Sally" uniqKey="Roufail S" first="Sally" last="Roufail">Sally Roufail</name><name sortKey="Stacker, Steven A" sort="Stacker, Steven A" uniqKey="Stacker S" first="Steven A." last="Stacker">Steven A. Stacker</name><name sortKey="Streltsov, Victor A" sort="Streltsov, Victor A" uniqKey="Streltsov V" first="Victor A." last="Streltsov">Victor A. Streltsov</name><name sortKey="Williams, Steven P" sort="Williams, Steven P" uniqKey="Williams S" first="Steven P." last="Williams">Steven P. 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